The fast, reproducible and uniform covalent modification of surfaces with molecules relevant for analytical purposes, such as antigens, antibodies or oligonucleotides, is a major issue in diagnostics. In addition, fully automated spotting of one or many different compounds on nanoliter scale is desirable. Celares GmbH, now Biosynth GmbH, in collaboration with Boehringer-Ingelheim, has developed a novel surface-modifying technology (celaCLICK) that addresses relevant surface-modification needs.

The principles of celaCLICK are depicted in the scheme below for modification of a gold surface.

celaCLICK scheme

Some unique selling points are:

  • Covalent attachment of proteins within seconds
  • Highly efficient conjugation
  • Very high density of the analytes
  • Directed attachment of analytes possible
  • Chips made with single or multiple analytes
  • Fully automated spotting of analytes on chips
  • Large volume range (from nanoliter to microliter)
  • No chemical coupling reagents with potential to interfere with surface or analyte

Our surface-modifying technology was co-developed with Boehringer-Ingelheim and is covered by patent applications associated with WO 2017/144359 A1.

Contact partner

Dr. Sophie Janke

Dr. Sophie Janke
Head of Synthesis

+49 30  9489 2350

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