The celares GmbH established many processes and techniques to manufacture bioconjugates as well as small-molecules and artificial polymers. A selection of available techniques is listed here.

Bioconjugates manufacturing:
- Activation of capped thiol-groups
- Reduction and re-folding (oxidation) of disulfide-bridged proteins and peptides
- Conjugation chemistries (selection)
- Reductive amination (including detector and scrubber for HCN)
- Activated esters or carbonates
- Thiol reactive groups
- Click chemistry
- Enzymatic conjugation
- Chromatography
- Tangential-flow filtration / ultrafiltration
- Batch size may range from 100 mg to 100 g
- Sterile filtration of drug substance in UDAF
Chemical compound manufacturing:
- Anionic polymerization of single or multiple, non-gaseous monomers
- Activation of polymers
- Handling and characterization of sensitive polymers and copolymers
- Temperature controlled reactions down to –15 °C
- Reactions in inert atmosphere
- Batch size may range from 100 g to 5 kg
- Safety relevant reactions (e.g., handling of toxic or flammable gases or products)
Small-volume liquid handling
High throughput production of components for diagnostics or lab-on-a-chip applications:
- Automated liquid handling of small volumes
- Drying or freeze-drying of small reagent solutions
- Functional quality control
Contact partner

Axel Priebsch
Head of Manufacturing
+49 30 9489 2350